ZNF761

Across TCGA patient cohorts, ZNF761 mutation is significantly associated with the total protein of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF761-associated genes across cancer lineages are PCNA, TIGAR, and Cyclin-B1. Each is linked with ZNF761 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF761-to-partner and partner-to-ZNF761 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ZNF761-low versus ZNF761-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF761→partner) and Y-score (partner→ZNF761) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.252	+2.000	<.001	<.001	3	4
UCEC	TIGAR →	+0.123	+1.425	.004	.002	3	4
UCEC	Cyclin-B1 →	+0.858	+2.237	<.001	<.001	3	3
UCEC	ACVRL1 →	-0.093	-1.132	.016	.049	3	3
UCEC	PDCD4 →	-0.503	-1.767	<.001	.001	3	3
UCEC	ATM →	-0.405	-2.074	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

PCNA by ZNF761 expression — UCEC

Explore this box plot interactively →