ZNF750

Across TCGA patient cohorts, ZNF750 mutation is significantly associated with the RNA expression of many other genes, with 2,814 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF750-associated genes across cancer lineages are INSL4, SKA1, and LARGE1. Each is linked with ZNF750 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF750-to-partner and partner-to-ZNF750 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INSL4 grouped by ZNF750-low versus ZNF750-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF750→partner) and Y-score (partner→ZNF750) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	INSL4 →	+0.866	+3.286	<.001	.008	3	4
UCEC	SKA1 →	+0.536	+1.847	.001	<.001	3	4
SKCM	LARGE1 →	+0.758	+3.469	.009	.002	3	3
UCEC	RMDN3 →	+0.447	+1.847	<.001	<.001	3	3
UCEC	CCDC43 →	+0.492	+2.147	<.001	<.001	3	3
UCEC	ADI1 →	+0.347	+2.040	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,814 associations by consensus.

INSL4 by ZNF750 expression — STAD

Explore this box plot interactively →