ZNF750

Across TCGA patient cohorts, ZNF750 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ZNF750-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and ERK2. Each is linked with ZNF750 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF750-to-partner and partner-to-ZNF750 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZNF750-low versus ZNF750-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF750→partner) and Y-score (partner→ZNF750) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.478	+2.242	.020	.005	3	3
UCEC	EGFR_pY1068 →	-0.251	-2.807	.003	.003	3	2
UCEC	ERK2 →	+0.190	+3.000	.004	<.001	3	2
UCEC	Rad50 →	-0.261	-1.736	.001	.007	3	2
UCEC	E-Cadherin →	+0.377	+3.013	.025	.018	3	2
STAD	FOXO3a_pS318_S321 →	-0.201	-2.978	.034	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Caspase-7-cleavedD198 by ZNF750 expression — UCEC

Explore this box plot interactively →