Across TCGA patient cohorts, ZNF749 mutation is significantly associated with the RNA expression of many other genes, with 1,749 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF749-associated genes across cancer lineages are MAP2K1, CKAP2L, and PPP2R2D. Each is linked with ZNF749 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF749-to-partner and partner-to-ZNF749 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF749→partner) and Y-score (partner→ZNF749) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAP2K1 →	+0.459	+1.673	.001	.003	3	3
UCEC	CKAP2L →	+0.543	+1.949	.004	.001	3	3
UCEC	PPP2R2D →	+0.275	+2.478	.001	.001	3	3
UCEC	RAD51 →	+0.621	+2.098	<.001	.002	3	3
UCEC	SPAG5 →	+0.550	+2.263	.002	<.001	3	3
UCEC	CDC6 →	+0.729	+1.960	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,749 associations by consensus.

Exploration

ZNF749 survival (RNA) · tumor vs normal (RNA) · all ZNF749 data types