Across TCGA patient cohorts, ZNF749 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF749-associated genes across cancer lineages are PCNA, ATM, and EGFR_pY1068. Each is linked with ZNF749 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF749-to-partner and partner-to-ZNF749 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF749→partner) and Y-score (partner→ZNF749) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.354	+3.008	.005	.019	3	2
COAD	ATM →	-0.723	-3.000	<.001	.034	3	2
UCEC	EGFR_pY1068 →	-0.193	-1.584	.032	.019	3	2
UCEC	eIF4E →	+0.171	+2.321	.024	.001	3	2
UCEC	PDCD4 →	-0.500	-1.925	.003	.005	3	2
UCEC	c-Kit →	-0.166	-1.584	.047	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

ZNF749 survival (RNA) · tumor vs normal (RNA) · all ZNF749 data types