Across TCGA cell cohorts, ZNF749 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ZNF749-associated genes across cancer lineages are TSPY2, CCR8, and TSPY8. Each is linked with ZNF749 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF749-to-partner and partner-to-ZNF749 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF749→partner) and Y-score (partner→ZNF749) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TSPY2 →	+0.016	+4.369	.001	.008	3	1
SOFT_TISSUE	CCR8 →	+0.016	+4.369	<.001	.008	3	1
SOFT_TISSUE	TSPY8 →	+0.016	+4.369	<.001	.008	3	1
OVARY	VCY →	+0.294	+4.228	<.001	.006	3	1
OVARY	PFN3 →	+0.057	+4.450	<.001	.004	3	1
LARGE_INTESTINE	SAA4 →	+0.676	+3.115	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

ZNF749 survival (RNA) · tumor vs normal (RNA) · all ZNF749 data types