ZNF746

Across TCGA patient cohorts, ZNF746 mutation is significantly associated with the RNA expression of many other genes, with 3,266 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF746-associated genes across cancer lineages are MTCO2P23, CHAF1B, and GLOD4. Each is linked with ZNF746 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF746-to-partner and partner-to-ZNF746 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCO2P23 grouped by ZNF746-low versus ZNF746-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF746→partner) and Y-score (partner→ZNF746) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	MTCO2P23 →	+0.081	+7.342	<.001	<.001	3	3
UCEC	CHAF1B →	+0.537	+3.016	.001	<.001	3	3
UCEC	GLOD4 →	+0.417	+2.534	.002	<.001	3	3
UCEC	TSR1 →	+0.420	+1.807	.004	.004	3	3
UCEC	PBK →	+0.725	+1.818	.003	.002	3	3
UCEC	MRM3 →	+0.398	+2.180	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,266 associations by consensus.

MTCO2P23 by ZNF746 expression — PRAD

Explore this box plot interactively →