ZNF746

Across TCGA cell cohorts, ZNF746 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible ZNF746-associated genes across cancer lineages are GPR139, CCDC195, and OR1N2. Each is linked with ZNF746 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF746-to-partner and partner-to-ZNF746 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR139 grouped by ZNF746-low versus ZNF746-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF746→partner) and Y-score (partner→ZNF746) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GPR139 →	+0.076	+4.736	<.001	.009	3	2
LARGE_INTESTINE	CCDC195 →	+0.037	+2.882	<.001	.005	3	2
BREAST	OR1N2 →	+0.043	+4.199	<.001	.007	3	1
SKIN	C2CD4B →	+0.046	+4.684	<.001	.002	3	1
SKIN	TMEM114 →	+0.048	+5.562	<.001	<.001	3	1
UPPER_AERODIGESTIVE_TRACT	PRAMEF2 →	+0.182	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

GPR139 by ZNF746 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →