ZNF740

Across TCGA pan-cancer cohorts, ZNF740 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZNF740 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF740 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF740 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where ZNF740 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.753	0.960	.001	22	view →
LUAD	OS	Tertile	All	1.000	0.674	.013	13	view →
LSCC	OS	Quartile	All	1.000	0.753	.006	10	view →
COAD	DFS	Median	III,IV	0.890	1.000	.032	6	view →
PDAC	DFS	Quartile	III,IV	0.155	0.977	.049	6	view →
CCRCC	OS	Median	II,III,IV	0.454	1.000	.014	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZNF740–HNSC (OS)

Open the HNSC breakdown →