ZNF740

Across TCGA patient cohorts, ZNF740 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF740-associated genes across cancer lineages are A-Raf_pS299, ERK2, and JNK_pT183_Y185. Each is linked with ZNF740 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF740-to-partner and partner-to-ZNF740 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ZNF740-low versus ZNF740-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF740→partner) and Y-score (partner→ZNF740) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.124	-2.321	.038	.035	3	1
UCEC	ERK2 →	+0.252	+2.321	.009	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.189	-2.308	.025	.036	3	1
UCEC	MAPK_pT202_Y204 →	-0.551	-2.321	.019	.035	3	1
UCEC	MEK1_p_S217_S221 →	-0.286	-2.321	.037	.035	3	1
UCEC	MEK1 →	+0.421	+3.000	.022	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

A-Raf_pS299 by ZNF740 expression — UCEC

Explore this box plot interactively →