Across TCGA pan-cancer cohorts, ZNF74 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF74 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher ZNF74 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF74 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BRCA, PRAD, and UCEC are the cancer types where ZNF74 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.166	0.579	.023	8	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	All	0.971	0.828	.021	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ZNF74 tumor-vs-normal RNA expression · all ZNF74 data types