Across TCGA patient cohorts, ZNF74 mutation is significantly associated with the RNA expression of many other genes, with 2,838 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF74-associated genes across cancer lineages are HIRIP3, LETM1, and TRABD. Each is linked with ZNF74 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF74-to-partner and partner-to-ZNF74 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF74→partner) and Y-score (partner→ZNF74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HIRIP3 →	+0.394	+2.148	.004	<.001	3	3
UCEC	LETM1 →	+0.504	+2.180	<.001	<.001	3	3
UCEC	TRABD →	+0.472	+2.555	<.001	<.001	3	3
UCEC	ZWILCH →	+0.501	+2.016	.001	.005	3	3
UCEC	RASSF1 →	+0.384	+2.158	<.001	.009	3	3
UCEC	RNF126 →	+0.449	+3.119	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,838 associations by consensus.

Exploration

ZNF74 survival (RNA) · tumor vs normal (RNA) · all ZNF74 data types