ZNF738

Across TCGA patient cohorts, ZNF738 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF738-associated genes across cancer lineages are PCNA, TFRC, and C-Raf. Each is linked with ZNF738 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF738-to-partner and partner-to-ZNF738 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ZNF738-low versus ZNF738-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF738→partner) and Y-score (partner→ZNF738) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.185	+1.523	.007	.008	3	2
UCEC	TFRC →	+0.553	+2.321	.001	.005	3	2
UCEC	C-Raf →	+0.125	+1.523	.006	.008	3	2
UCEC	14-3-3_beta →	-0.096	-2.388	.002	.002	3	1
UCEC	eIF4E →	+0.156	+1.523	.020	.008	3	1
UCEC	A-Raf_pS299 →	-0.132	-3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PCNA by ZNF738 expression — UCEC

Explore this box plot interactively →