ZNF737

Across TCGA patient cohorts, ZNF737 mutation is significantly associated with the RNA expression of many other genes, with 4,138 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF737-associated genes across cancer lineages are DDX49, PELP1, and TINAGL1. Each is linked with ZNF737 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF737-to-partner and partner-to-ZNF737 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDX49 grouped by ZNF737-low versus ZNF737-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF737→partner) and Y-score (partner→ZNF737) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DDX49 →	+0.528	+3.193	<.001	.009	3	3
HNSC	PELP1 →	+0.669	+3.192	<.001	.009	3	3
HNSC	TINAGL1 →	-1.487	-3.447	<.001	.005	3	3
UCEC	ZNF852 →	+0.347	+3.724	.001	<.001	3	3
UCEC	GLRX5 →	+0.358	+2.658	.006	.005	3	3
UCEC	DRG1 →	+0.387	+3.732	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,138 associations by consensus.

DDX49 by ZNF737 expression — HNSC

Explore this box plot interactively →