ZNF737

Across TCGA patient cohorts, ZNF737 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF737-associated genes across cancer lineages are JNK_pT183_Y185, eEF2K, and Raptor. Each is linked with ZNF737 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF737-to-partner and partner-to-ZNF737 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by ZNF737-low versus ZNF737-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF737→partner) and Y-score (partner→ZNF737) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.214	-3.700	.002	.001	3	3
LUSC	eEF2K →	+0.322	+3.331	.047	.005	3	2
SKCM	Raptor →	+0.222	+2.321	.004	.032	3	2
SKCM	Tuberin →	+0.345	+3.321	.014	.009	3	2
UCEC	C-Raf →	+0.178	+2.000	.002	.030	3	2
UCEC	ERK2 →	+0.209	+2.584	.008	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

JNK_pT183_Y185 by ZNF737 expression — UCEC

Explore this box plot interactively →