ZNF736

Across TCGA patient cohorts, ZNF736 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF736-associated genes across cancer lineages are TIGAR, A-Raf_pS299, and IGFBP2. Each is linked with ZNF736 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF736-to-partner and partner-to-ZNF736 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by ZNF736-low versus ZNF736-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF736→partner) and Y-score (partner→ZNF736) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.115	+1.584	.032	.034	3	2
UCEC	A-Raf_pS299 →	-0.097	-2.392	.020	<.001	3	1
UCEC	IGFBP2 →	-0.571	-1.906	.012	.015	3	1
UCEC	JNK2 →	+0.189	+2.000	.007	.003	3	1
UCEC	MEK1 →	+0.258	+1.906	.046	.015	3	1
UCEC	p27_pT198 →	+0.111	+1.662	.003	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

TIGAR by ZNF736 expression — UCEC

Explore this box plot interactively →