Across TCGA pan-cancer cohorts, ZNF735 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF735 data layer compared with 16 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNF735 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF735 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, SKCM, and SCLC are the cancer types where ZNF735 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.974	0.613	.002	30	view →
SKCM	DFS	Median	II,III,IV	0.898	0.654	.006	8	view →
SCLC	DFS	Median	All	0.164	0.581	.005	6	view →
PRAD	DFS	Median	All	0.106	0.776	<.001	6	view →
LIHC	OS	Median	II,III,IV	0.255	0.768	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ZNF735 tumor-vs-normal RNA expression · all ZNF735 data types