Across TCGA patient cohorts, ZNF729 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. SCLC shows the largest number of these associations.

The most reproducible ZNF729-associated genes across cancer lineages are WNT5B, FHL5, and ARHGEF4. Each is linked with ZNF729 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF729-to-partner and partner-to-ZNF729 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF729→partner) and Y-score (partner→ZNF729) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	WNT5B →	+1.349	+2.044	.009	.005	3	1
SCLC	FHL5 →	+0.942	+2.622	.002	.003	3	1
SCLC	ARHGEF4 →	-1.153	-3.321	.001	.004	3	1
SCLC	SULT6B1 →	+0.057	+2.022	.001	.006	3	1
SCLC	KCNJ1 →	+0.055	+2.750	<.001	.004	3	1
SCLC	FBXL2 →	-1.400	-2.547	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

ZNF729 survival (RNA) · tumor vs normal (RNA) · all ZNF729 data types