ZNF728

Across TCGA pan-cancer cohorts, ZNF728 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF728 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ZNF728 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF728 expression acts as an unfavorable survival marker.

CESC, LUAD, and BLCA are the cancer types where ZNF728 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.241	0.747	<.001	12	view →
LUAD	OS	Median	III,IV	0.142	0.690	<.001	12	view →
BLCA	OS	Median	All	0.168	0.592	.028	6	view →
SKCM	DFS	Median	III,IV	0.131	0.654	.005	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF728–CESC (DFS)

Open the CESC breakdown →