Across TCGA pan-cancer cohorts, ZNF726 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF726 data layer compared with 28 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher ZNF726 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF726 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

READ, COAD, and UCEC are the cancer types where ZNF726 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.111	0.919	<.001	33	view →
COAD	OS	Median	All	0.111	0.871	<.001	12	view →
UCEC	DFS	Median	All	1.000	0.635	.025	8	view →
SARC	DFS	Median	All	0.121	0.591	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ZNF726 tumor-vs-normal RNA expression · all ZNF726 data types