Across TCGA patient cohorts, ZNF721 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF721-associated genes across cancer lineages are PCNA, c-Jun_pS73, and ERK2. Each is linked with ZNF721 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF721-to-partner and partner-to-ZNF721 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF721→partner) and Y-score (partner→ZNF721) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.287	+2.178	.013	.035	3	3
COAD	c-Jun_pS73 →	-0.198	-3.279	.007	.010	3	3
UCEC	ERK2 →	+0.116	+1.678	.032	.019	3	3
UCEC	PDCD4 →	-0.534	-1.632	<.001	<.001	3	3
UCEC	Rictor_pT1135 →	-0.067	-1.392	.019	.017	3	3
UCEC	Src_pY527 →	-0.291	-1.807	.016	.024	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

Exploration

ZNF721 survival (RNA) · tumor vs normal (RNA) · all ZNF721 data types