ZNF718

Across TCGA patient cohorts, ZNF718 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF718-associated genes across cancer lineages are Lck, MEK1, and PDCD4. Each is linked with ZNF718 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF718-to-partner and partner-to-ZNF718 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by ZNF718-low versus ZNF718-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF718→partner) and Y-score (partner→ZNF718) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.151	+2.321	.037	.034	3	2
UCEC	MEK1 →	+0.548	+3.906	<.001	<.001	3	2
UCEC	PDCD4 →	-0.565	-2.115	<.001	.016	3	2
UCEC	PI3K-p110-a →	-0.126	-2.321	.047	.001	3	2
UCEC	ATM →	-0.615	-2.687	<.001	.005	3	2
UCEC	Di-Ras3 →	-0.122	-2.446	.022	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Lck by ZNF718 expression — UCEC

Explore this box plot interactively →