ZNF716

Across TCGA patient cohorts, ZNF716 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF716-associated genes across cancer lineages are Cyclin-B1, ACC1, and PI3K-p110-a. Each is linked with ZNF716 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF716-to-partner and partner-to-ZNF716 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ZNF716-low versus ZNF716-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF716→partner) and Y-score (partner→ZNF716) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.695	+2.432	<.001	<.001	3	4
LUAD	ACC1 →	+0.544	+2.338	<.001	.017	3	3
COAD	PI3K-p110-a →	+0.126	+3.178	.037	.010	3	3
COAD	ASNS →	+0.720	+3.000	<.001	.035	3	3
SKCM	TSC1 →	-0.226	-1.700	.009	.043	3	3
LUAD	p70-S6K →	+0.248	+3.321	.003	.009	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Cyclin-B1 by ZNF716 expression — UCEC

Explore this box plot interactively →