ZNF716

Across TCGA cell cohorts, ZNF716 mutation is significantly associated with the RNA expression of many other genes, with 218 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF716-associated genes across cancer lineages are C1orf216, LCE1A, and SCGB1D2. Each is linked with ZNF716 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF716-to-partner and partner-to-ZNF716 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf216 grouped by ZNF716-low versus ZNF716-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF716→partner) and Y-score (partner→ZNF716) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1orf216 →	+0.792	+3.502	<.001	.001	3	2
LUNG_NSCLC_LUSC	LCE1A →	+0.126	+4.643	<.001	.008	3	1
CNS	SCGB1D2 →	+0.415	+3.358	.005	.009	3	1
CNS	OR4D1 →	+0.029	+3.196	.001	.004	3	1
CNS	PTCRA →	+0.134	+3.196	<.001	.004	3	1
CNS	MRGPRX4 →	+0.712	+4.079	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 218 associations by consensus.

C1orf216 by ZNF716 expression — LARGE_INTESTINE

Explore this box plot interactively →