ZNF708

Across TCGA patient cohorts, ZNF708 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF708-associated genes across cancer lineages are Cyclin-B1, Notch1, and ASNS. Each is linked with ZNF708 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF708-to-partner and partner-to-ZNF708 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ZNF708-low versus ZNF708-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF708→partner) and Y-score (partner→ZNF708) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.606	+2.070	.001	.001	3	3
UCEC	Notch1 →	+0.142	+1.817	.003	.015	3	2
UCEC	ASNS →	+0.407	+1.440	.001	.024	3	2
UCEC	JNK_pT183_Y185 →	-0.152	-1.723	.009	.007	3	1
UCEC	JNK2 →	+0.174	+1.736	.011	.007	3	1
UCEC	Ku80 →	+0.224	+1.453	.006	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Cyclin-B1 by ZNF708 expression — UCEC

Explore this box plot interactively →