ZNF708

Across TCGA cell cohorts, ZNF708 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,744 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF708-associated GO terms across cancer lineages are Regulation of double-strand break repair, Positive regulation of double-strand break repair, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with ZNF708 in more than 14 cancer types. Because this analysis shows association rather than direction, both ZNF708-to-partner and partner-to-ZNF708 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of double-strand break repair grouped by ZNF708-low versus ZNF708-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF708→partner) and Y-score (partner→ZNF708) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of double-strand break repair →	+0.072	+0.725	.003	.003	3	15
BONE	Positive regulation of double-strand break repair →	+0.089	+0.838	<.001	<.001	3	14
OVARY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.096	+0.838	.001	.001	3	13
SOFT_TISSUE	Regulation of double-strand break repair via homologous recombination →	+0.107	+1.033	<.001	<.001	3	13
LUNG_SCLC	Vesicle tethering →	+0.070	+1.031	<.001	<.001	3	13
BONE	Constitutive heterochromatin formation →	+0.125	+1.033	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,744 associations by consensus.

Regulation of double-strand break repair by ZNF708 expression — BONE

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