Across TCGA pan-cancer cohorts, ZNF70 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZNF70’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF70 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF70 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.
KIRC, THCA, and HNSC are the cancer types where ZNF70 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF70 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.