ZNF7

Across TCGA pan-cancer cohorts, ZNF7 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF7 data layer compared with 21 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ZNF7 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF7 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, BLCA, and HNSC are the cancer types where ZNF7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.028	0.668	<.001	18	view →
BLCA	OS	Median	All	0.257	0.620	.031	12	view →
HNSC	OS	Median	All	0.174	0.685	.022	9	view →
UCEC	DFS	Median	All	0.968	0.829	.025	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF7–COAD (DFS)

Open the COAD breakdown →