ZNF7

Across TCGA patient cohorts, ZNF7 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF7-associated genes across cancer lineages are eIF4E, PDCD4, and ATM. Each is linked with ZNF7 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF7-to-partner and partner-to-ZNF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZNF7-low versus ZNF7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF7→partner) and Y-score (partner→ZNF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.183	+1.662	.014	.011	3	2
UCEC	PDCD4 →	-0.520	-2.584	.001	.010	3	2
UCEC	ATM →	-0.387	-1.861	.015	.049	3	2
COAD	Caspase-7-cleavedD198 →	+0.952	+2.815	.028	.036	2	3
UCEC	4E-BP1 →	+0.217	+1.874	.023	.049	3	2
UCEC	14-3-3_beta →	-0.094	-2.673	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eIF4E by ZNF7 expression — UCEC

Explore this box plot interactively →