ZNF7

Across TCGA cell cohorts, ZNF7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,133 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ZNF7-associated GO terms across cancer lineages are miRNA-mediated gene silencing by mRNA destabilization, Regulation of nucleotide-excision repair, and Positive regulation of DNA repair. Each is linked with ZNF7 in more than 11 cancer types. Because this analysis shows association rather than direction, both ZNF7-to-partner and partner-to-ZNF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, miRNA-mediated gene silencing by mRNA destabilization grouped by ZNF7-low versus ZNF7-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF7→partner) and Y-score (partner→ZNF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	miRNA-mediated gene silencing by mRNA destabilization →	+0.122	+0.468	<.001	<.001	3	12
BONE	Regulation of nucleotide-excision repair →	+0.137	+0.934	<.001	<.001	3	12
BONE	Positive regulation of DNA repair →	+0.079	+1.029	<.001	<.001	3	11
BONE	Cellular response to salt →	+0.120	+0.857	<.001	<.001	3	11
SOFT_TISSUE	Positive regulation of sister chromatid cohesion →	+0.129	+0.602	<.001	<.001	3	11
BONE	Regulation of DNA repair →	+0.085	+0.903	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,133 associations by consensus.

miRNA-mediated gene silencing by mRNA destabilization by ZNF7 expression — LUNG_SCLC

Explore this box plot interactively →