ZNF7

Across TCGA cell cohorts, ZNF7 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF7-associated genes across cancer lineages are MSGN1, SPRR2F, and KLF18. Each is linked with ZNF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF7-to-partner and partner-to-ZNF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by ZNF7-low versus ZNF7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF7→partner) and Y-score (partner→ZNF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	SPRR2F →	+0.464	+3.707	.008	.009	3	1
LARGE_INTESTINE	KLF18 →	+0.009	+3.930	<.001	.003	3	1
LUNG_NSCLC_LUAD	WFDC6 →	+0.050	+4.887	<.001	.009	3	1
BLOOD_Leukemia	PPP1R2C →	+0.230	+4.539	<.001	.007	3	1
BLOOD_Leukemia	CST8 →	+0.046	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MSGN1 by ZNF7 expression — LARGE_INTESTINE

Explore this box plot interactively →