Across TCGA patient cohorts, ZNF699 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF699-associated genes across cancer lineages are eIF4E, Notch1, and 4E-BP1. Each is linked with ZNF699 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF699-to-partner and partner-to-ZNF699 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF699→partner) and Y-score (partner→ZNF699) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.251	+3.321	.006	.010	3	3
UCEC	Notch1 →	+0.110	+1.392	.017	.019	3	2
UCEC	4E-BP1 →	+0.357	+3.087	<.001	<.001	3	2
UCEC	A-Raf_pS299 →	-0.102	-2.321	.009	.005	3	1
UCEC	JNK2 →	+0.219	+2.834	<.001	.001	3	1
UCEC	MEK1 →	+0.396	+1.938	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

ZNF699 survival (RNA) · tumor vs normal (RNA) · all ZNF699 data types