ZNF697

Across TCGA pan-cancer cohorts, ZNF697 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ZNF697’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZNF697 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF697 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where ZNF697 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF697 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.853	<.001	12	view →
COAD	Male	All	+1.149	<.001	11	view →
BLCA	All	III,IV	+1.217	<.001	10	view →
KICH	Male	II,III,IV	−2.130	<.001	8	view →
STAD	Male	II,III,IV	+1.227	<.001	8	view →
THCA	Male	All	−0.580	<.001	6	view →
KIRC	Male	II,III,IV	−0.574	<.001	6	view →
LIHC	All	All	+0.569	<.001	6	view →
READ	All	All	+1.402	<.001	5	view →
LUAD	Male	All	+0.546	.009	5	view →
CHOL	All	All	+1.485	.001	4	view →
LUSC	Male	II,III,IV	+0.815	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ZNF697–HNSC

Open the HNSC breakdown →