Across TCGA pan-cancer cohorts, ZNF697 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of ZNF697’s most consistent transcriptional readouts.
The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where ZNF697 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ZNF697 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.
CCRCC are the cancer types where ZNF697 tumor–normal differential expression is most reproducible.