ZNF692

Across TCGA patient cohorts, ZNF692 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF692-associated genes across cancer lineages are MEK1, p62 Lck ligand, and ATM. Each is linked with ZNF692 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF692-to-partner and partner-to-ZNF692 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZNF692-low versus ZNF692-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF692→partner) and Y-score (partner→ZNF692) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.499	+2.938	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.310	+2.331	.006	.003	3	2
UCEC	ATM →	-0.402	-1.736	.010	.007	3	2
UCEC	Caspase-7-cleavedD198 →	+0.696	+1.522	<.001	.017	3	2
UCEC	14-3-3_beta →	-0.110	-2.780	.001	.003	3	1
UCEC	eEF2 →	+0.266	+2.321	.032	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

MEK1 by ZNF692 expression — UCEC

Explore this box plot interactively →