ZNF689

Across TCGA patient cohorts, ZNF689 mutation is significantly associated with the RNA expression of many other genes, with 755 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF689-associated genes across cancer lineages are PPCDC, HMGN2P16, and NPBWR2. Each is linked with ZNF689 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF689-to-partner and partner-to-ZNF689 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPCDC grouped by ZNF689-low versus ZNF689-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF689→partner) and Y-score (partner→ZNF689) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PPCDC →	+0.404	+3.223	.006	.009	3	2
SKCM	HMGN2P16 →	+0.175	+3.801	<.001	.007	3	2
CESC	NPBWR2 →	+0.036	+5.010	<.001	.009	3	2
BLCA	MIR548I1 →	+0.379	+4.463	<.001	.005	3	2
BLCA	LINC02216 →	+0.093	+4.463	.002	.005	3	2
BLCA	RNU6-389P →	+0.324	+4.588	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 755 associations by consensus.

PPCDC by ZNF689 expression — COAD

Explore this box plot interactively →