ZNF689

Across TCGA patient cohorts, ZNF689 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF689-associated genes across cancer lineages are EGFR_pY1068, Lck, and MEK1. Each is linked with ZNF689 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF689-to-partner and partner-to-ZNF689 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNF689-low versus ZNF689-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF689→partner) and Y-score (partner→ZNF689) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.222	-3.169	.037	.019	3	2
UCEC	Lck →	+0.181	+1.700	.033	.044	3	2
UCEC	MEK1 →	+0.480	+3.459	.001	.005	3	1
UCEC	MSH2 →	-0.323	-3.295	<.001	.009	3	1
UCEC	NF2 →	+0.198	+3.169	.031	.019	3	1
UCEC	p62 Lck ligand →	+0.366	+2.469	.008	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by ZNF689 expression — UCEC

Explore this box plot interactively →