ZNF689

Across TCGA cell cohorts, ZNF689 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,699 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ZNF689-associated GO terms across cancer lineages are Interstrand cross-link repair, Regulation of chromatin organization, and Regulation of translational fidelity. Each is linked with ZNF689 in more than 15 cancer types. Because this analysis shows association rather than direction, both ZNF689-to-partner and partner-to-ZNF689 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Interstrand cross-link repair grouped by ZNF689-low versus ZNF689-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF689→partner) and Y-score (partner→ZNF689) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Interstrand cross-link repair →	+0.093	+0.892	<.001	<.001	3	16
BONE	Regulation of chromatin organization →	+0.098	+0.698	<.001	<.001	3	15
SKIN	Regulation of translational fidelity →	+0.107	+1.125	<.001	<.001	3	15
BONE	Regulation of double-strand break repair via homologous recombination →	+0.138	+0.793	<.001	<.001	3	13
SKIN	Aminoacyl-tRNA metabolism involved in translational fidelity →	+0.138	+1.475	<.001	<.001	3	13
SOFT_TISSUE	CAMP/PKA signal transduction →	+0.176	+0.703	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,699 associations by consensus.

Interstrand cross-link repair by ZNF689 expression — UPPER_AERODIGESTIVE_TRACT

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