ZNF689

Across TCGA cell cohorts, ZNF689 mutation is significantly associated with the RNA expression of many other genes, with 61 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF689-associated genes across cancer lineages are IFNG, SPATA19, and MAGEB5. Each is linked with ZNF689 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF689-to-partner and partner-to-ZNF689 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNG grouped by ZNF689-low versus ZNF689-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF689→partner) and Y-score (partner→ZNF689) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IFNG →	+0.128	+2.982	.001	.007	3	2
BLOOD_Leukemia	SPATA19 →	+0.012	+4.247	<.001	.004	3	2
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
UPPER_AERODIGESTIVE_TRACT	TSPY8 →	+0.023	+5.357	<.001	.003	3	1
BLOOD_Leukemia	SLC32A1 →	+0.688	+3.223	<.001	.004	3	1
BLOOD_Leukemia	FGF14 →	+0.305	+3.656	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

IFNG by ZNF689 expression — BLOOD_Leukemia

Explore this box plot interactively →