ZNF688

Across TCGA pan-cancer cohorts, ZNF688 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF688 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZNF688 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF688 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where ZNF688 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.864	0.208	.014	19	view →
CCRCC	DFS	Tertile	All	0.534	0.906	.004	13	view →
HNSC	DFS	Median	IV	0.682	0.930	.018	8	view →
PDAC	DFS	Quartile	All	0.390	0.753	.017	5	view →
LSCC	DFS	Median	All	0.999	0.861	.003	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF688–LUAD (DFS)

Open the LUAD breakdown →