ZNF688

Across TCGA pan-cancer cohorts, ZNF688 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of ZNF688’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where ZNF688 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ZNF688 is over-expressed in tumor, although a few such as PDAC and LSCC show the opposite, repressed pattern.

PDAC, LSCC, and CCRCC are the cancer types where ZNF688 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF688 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	II,III,IV	−0.613	<.001	6	view →
LSCC	Female	III,IV	−0.547	.043	1	view →
CCRCC	Female	IV	−0.364	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

ZNF688–PDAC

Open the PDAC breakdown →