ZNF688

Across TCGA patient cohorts, ZNF688 mutation is significantly associated with the RNA expression of many other genes, with 1,367 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF688-associated genes across cancer lineages are SNX3P1Y, KIR3DL1, and MIR5787. Each is linked with ZNF688 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF688-to-partner and partner-to-ZNF688 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNX3P1Y grouped by ZNF688-low versus ZNF688-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF688→partner) and Y-score (partner→ZNF688) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNX3P1Y →	+0.088	+4.308	<.001	.003	3	2
COAD	KIR3DL1 →	+0.359	+3.652	<.001	.007	3	2
CESC	MIR5787 →	+0.393	+4.384	<.001	.008	3	2
CESC	NF1P10 →	+0.289	+4.984	<.001	.003	3	2
SKCM	MIR4739 →	+0.317	+5.408	<.001	.002	3	2
UCEC	TXN2P1 →	+0.313	+2.032	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,367 associations by consensus.

SNX3P1Y by ZNF688 expression — UCEC

Explore this box plot interactively →