ZNF688

Across TCGA patient cohorts, ZNF688 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF688-associated genes across cancer lineages are Akt, eIF4E, and Shc_pY317. Each is linked with ZNF688 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF688-to-partner and partner-to-ZNF688 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt grouped by ZNF688-low versus ZNF688-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF688→partner) and Y-score (partner→ZNF688) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt →	-0.227	-3.449	.019	.005	3	3
UCEC	eIF4E →	+0.179	+3.183	.046	.009	3	2
UCEC	Shc_pY317 →	-0.269	-2.906	<.001	.001	3	2
UCEC	ATM →	-0.570	-3.156	.003	.018	3	2
UCEC	eEF2 →	+0.458	+4.000	.002	<.001	3	1
UCEC	EGFR_pY1068 →	-0.332	-3.321	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Akt by ZNF688 expression — UCEC

Explore this box plot interactively →