ZNF688

Across TCGA cell cohorts, ZNF688 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF688-associated genes across cancer lineages are C1QTNF7, WFDC11, and OR1D4. Each is linked with ZNF688 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF688-to-partner and partner-to-ZNF688 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QTNF7 grouped by ZNF688-low versus ZNF688-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF688→partner) and Y-score (partner→ZNF688) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1QTNF7 →	+0.076	+4.108	.002	.008	3	1
BLOOD_Leukemia	WFDC11 →	+0.030	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR1D4 →	+0.046	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

C1QTNF7 by ZNF688 expression — LARGE_INTESTINE

Explore this box plot interactively →