ZNF687

Across TCGA pan-cancer cohorts, ZNF687 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ZNF687’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ZNF687 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF687 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LUAD, LSCC, and HNSC are the cancer types where ZNF687 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF687 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	+0.541	<.001	9	view →
LSCC	Male	II,III,IV	+0.755	<.001	8	view →
HNSC	Male	III,IV	+0.311	<.001	8	view →
PDAC	All	II,III,IV	−0.160	.007	2	view →
COAD	All	All	+0.122	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ZNF687–LUAD

Open the LUAD breakdown →