ZNF687

Across TCGA patient cohorts, ZNF687 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF687-associated genes across cancer lineages are eEF2, GAPDH, and p90 RSK_pT359_S363. Each is linked with ZNF687 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF687-to-partner and partner-to-ZNF687 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ZNF687-low versus ZNF687-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF687→partner) and Y-score (partner→ZNF687) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.245	+2.115	.025	.016	3	3
UCEC	GAPDH →	+0.362	+2.222	.027	.009	3	3
UCEC	p90 RSK_pT359_S363 →	-0.151	-1.999	.014	.008	3	3
BLCA	PCNA →	+0.219	+3.169	.029	.019	3	2
UCEC	Gab2 →	+0.232	+1.415	.034	.043	3	2
UCEC	MSH2 →	-0.221	-2.295	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

eEF2 by ZNF687 expression — UCEC

Explore this box plot interactively →