ZNF684

Across TCGA pan-cancer cohorts, ZNF684 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ZNF684 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ZNF684 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF684 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP and UCEC are the cancer types where ZNF684 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.111	0.934	<.001	42	view →
UCEC	DFS	Median	All	1.000	0.621	.016	22	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

ZNF684–KIRP (OS)

Open the KIRP breakdown →