ZNF684

Across TCGA patient cohorts, ZNF684 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,297 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ZNF684-associated proteins across cancer lineages are SMAD4, DEK, and DNAJC8. Each is linked with ZNF684 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZNF684-to-partner and partner-to-ZNF684 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZNF684 versus SMAD4 in PDAC, with a Pearson correlation of 0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF684→partner) and Y-score (partner→ZNF684) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SMAD4 →	+0.223	+0.263	<.001	.001	3	5
HNSC	DEK →	+0.357	+0.622	<.001	<.001	3	5
GBM	DNAJC8 →	+0.412	+0.456	<.001	<.001	3	5
GBM	ARID4B →	+0.313	+0.371	<.001	<.001	3	4
GBM	NELFA →	+0.292	+0.425	<.001	<.001	3	4
GBM	NELFB →	+0.345	+0.345	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,297 associations by consensus.

ZNF684 vs SMAD4 — PDAC

Explore this scatter interactively →