ZNF684

Across TCGA patient cohorts, ZNF684 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF684-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and Acetyl-a-Tubulin-Lys40. Each is linked with ZNF684 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF684-to-partner and partner-to-ZNF684 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNF684-low versus ZNF684-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF684→partner) and Y-score (partner→ZNF684) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.297	-2.321	.006	.033	3	1
UCEC	FoxM1 →	+0.352	+3.469	.001	.002	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.484	+2.807	.029	.003	3	1
UCEC	Ku80 →	+0.232	+2.128	.024	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.245	+1.598	.006	.044	3	1
UCEC	Notch1 →	+0.184	+2.820	.002	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by ZNF684 expression — UCEC

Explore this box plot interactively →