ZNF683

Across TCGA patient cohorts, ZNF683 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF683-associated genes across cancer lineages are c-Kit, Cyclin-B1, and EGFR_pY1173. Each is linked with ZNF683 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF683-to-partner and partner-to-ZNF683 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by ZNF683-low versus ZNF683-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF683→partner) and Y-score (partner→ZNF683) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Kit →	-0.186	-2.986	.047	.035	3	2
UCEC	Cyclin-B1 →	+0.524	+3.169	.020	.019	3	2
SKCM	EGFR_pY1173 →	+0.111	+2.459	.002	.017	3	1
SKCM	G6PD →	-0.194	-2.442	.017	.017	3	1
SKCM	HER2_pY1248 →	+0.211	+1.713	<.001	.024	3	1
SKCM	HER3_pY1289 →	+0.075	+2.203	.041	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

c-Kit by ZNF683 expression — UCEC

Explore this box plot interactively →